This disorder, which is most prevalent in women, usually results from a dysfunction of the thyroid gland caused by surgery, irradiation therapy, chronic autoimmune thyroiditis (Hashimoto's disease), or inflammatory conditions, such as amyloidosis and sarcoidosis. Besides an enlarged thyroid, signs and symptoms include weight gain despite anorexia, fatigue, cold intolerance, constipation; menorrhagia; slowed intellectual and motor activity; dry pale, cool skin; dry sparse hair; and thick, brittle nails. Eventually, the face assumes a dull expression with periorbital edema.
(info found @ Professional Guide to Signs & Symptoms 5th ed. Lippincott Williams & Wilkins)
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